Significant Health Issue in US Both Military and Civilian.
No FDA nor DOD approved therapeutics.
NIH grant award for $3.2MM to develop MP-201.
Cofunded BrightFocus/MTEC Grant for MP-201 IND enabling $500,000.
TBI causes impaired mitochondrial respiration (low oxygen consumption) and high ROS production, calcium overload.
TBI Model: cortical impact.
Treatment: 80 mg/kg MP201 (Mice) 2-hours post injury for 2 weeks.
Increased cortical sparing (p <0.01; 38% lesion spared).
Improved cognitive outcome (p<0.05).