Mitochon Pipeline
Compounds
MP101
MP201
Pre-Clinical Efficacy
IND Enabling Activities
Phase I
Phase II
Parkinson’s Disease
- The Sirt3 KO mouse model, exhibits increased vulnerability of striatal and hippocampal neurons to degeneration.
- 6-OHDA in PBS injected into the right striatum of Sirt3 KO under stereotaxic guidance, the dopaminergic neurons are destroyed.
- Prior to rotarod behavioral testing, MP101 was provided orally once per day for 14-days.
OUR DATA SHOWS: MP101 Preserves Dopaminergic Neurons (TH+).
MP101 has a striking effect on behavior on the rotarod.
MP101 Preserves Dopaminergic Neurons (TH+).
6-OHDA model has selectively kill dopaminergic SN neurons slowly over the two weeks post-injection (ipsilateral side). The day after the injection the mice begin a two week treatment with MP101 at 1 and 5mpk, but the SN neurons are protected from eminent cell death (TH positive).
MP101 has a striking effect on behavior on the rotarod.
MP101 treated mice stay on the rotarod 4x longer than placebo.
Rotarod Test after 14-Days of Chronic Treatment with MP101 Showing Neuroprotection Against 6-OHDA-induced Degeneration of the Dopaminergic Neurons in the Nigrostriatal Pathway of Sirt3 KO mice.