Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis

Optic neuritis is an inflammatory demyelinating disease of the optic nerve often associated with multiple sclerosis (MS) [1]. Optic neuritis may lead to complete or partial loss of vision in one or both eyes [2]. In 15%–20% of people who eventually develop MS, optic neuritis is their first symptom [3]. Current therapies used for optic neuritis, intravenous corticosteroids, show no benefit on final visual recovery, with up to 60% of patients failing to return to normal visual function, even though steroids have an effect in hastening acute visual recovery, decreasing inflammation, and reducing pain on eye movement associated with optic neuritis [1, 4].

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