Mitochon Pharmaceuticals » Logo
Mitochon Pipeline
Mitochon Pipeline
Compounds
Preclinical Efficacy
IND Enabling Activities
Phase I
Phase II

Huntington’s Disease

Neurodegenerative disorder resulting in chorea, eventual dementia and premature death. Genetic mutation in huntingtin gene, a “tri-nucleotide repeat expansion disorder” of CAG (glutamine).
Transgenic mouse, N171-82Q, expressing a cDNA encoding the N-terminal fragment of a 171 amino acids of the huntingtin gene with 82 glutamine repeats.
Similar to humans, these transgenic mice have the “premanifest” stage prior to showing movement disorders, striatum, intranuclear inclusion / neuritic aggregates and premature death.
HD mice were treated ~ 17-weeks with MP101 by daily oral gavage.

Our Data Shows:

MP101 Preserves Brain Volume, Medium Spiny Neurons and General Neurons.
MP101 Preserves Movement.
MP101 Significantly Protects from Reactive Oxygen Species in the Cortex.

MP101 Preserves Brain Volume, Medium Spiny Neurons and General Neurons.

MP101 Preserves Brain Volume Medium Spinal Neurons » Mitochon PharmaceuticalsMP101 Preserves Brain Volume General Neurons » Mitochon Pharmaceuticals
Wu, B, Experimental Neurology, 2017 March 27

MP101 Improves Motor Function in a N171-82Q HD Mouse of Huntingon's Disease at Age 26W with 17W Treatment.

MP101 Improves Motor Function Balance Beam » Mitochon PharmaceuticalsMP101 Improves Motor Function Tapered Beam » Mitochon Pharmaceuticals
The values are the mean and SEM. One-way ANOVA tests were used. n=14-16. *p<0.005 versus the WT Placebo group; #p<0.005 versus the HD Placebo group.
Wu, B, Experimental Neurology, 2017 March 27

MP101 attenuates brain atrophy (at 26 weeks of age) in N171-82 HD mice.

MP101 Attenuates Brain Atrophy Wildtype » Mitochon PharmaceuticalsMP101 Attenuates Brain Atrophy HD » Mitochon PharmaceuticalsMP101 Attenuates Brain Atrophy HD-MP101 » Mitochon Pharmaceuticals
Wildtype (WT) with normal cortex (Ctx) and Striatum (Str). HD placebo (HD) shows loss in both Ctx and Str. MP-101 shows minor loss in Ctx and Str.

MP101 Significantly Reduces Oxidative Stress in Cortex of HD Mouse Model.

MP101 Lowers Isoprostanes and Neurofilament Light Chain (NfL) in HD Mice » Mitochon Pharmaceuticals
The values are the mean and SEM. One-way ANOVA tests were used. n=14-16. *p<0.005 versus the WT Placebo group; #p<0.005 versus the HD Placebo group.
Wu, B, Experimental Neurology, 2017 March 27

Contact Us

We would like to hear from you if you want information on our endeavors or wish to learn more about our research efforts.
crosschevron-upchevron-down