Mitochon Pharmaceuticals Announces First Patent Allowance for Mitochondrial Targeted Therapies for Neurodegeneration

Blue Bell, Pennsylvania (BUSINESS WIRE) — Mitochon Pharmaceuticals today announced that it was notified by the US Patent and Trade Mark Office of allowance on its first patent, US 15/002,531 “INDUCED EXPRESSION OF BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) FOR TREATMENT OF NEUROMUSCULAR, NEURODEGENERATIVE, AUTOIMMUNE, DEVELOPMENTAL AND/OR METABOLIC DISEASE”. This patent allowance will help…(Read More)

Mitochon Pharmaceuticals Awarded Grant from The Michael J. Fox Foundation to Support Mitochondrial Research in Parkinson’s

Blue Bell, Pennsylvania (BUSINESS WIRE)–Mitochon Pharmaceuticals today announced that it was awarded a grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to help develop its mitochondrial targeted compounds for treating Parkinson’s disease. The funding will go to pivotal animal studies to assess the benefits of Mitochon’s compounds in…(Read More)

Mitochondrial Uncoupler Prodrug of 2,4-Dinitrophenol, MP201, Prevents Neuronal Damage and Preserves Vision in Experimental Optic Neuritis

Optic neuritis is an inflammatory demyelinating disease of the optic nerve often associated with multiple sclerosis (MS) [1]. Optic neuritis may lead to complete or partial loss of vision in one or both eyes [2]. In 15%–20% of people who eventually develop MS, optic neuritis is their first symptom [3]. Current therapies used for…(Read More)

2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the first exon of the gene huntingtin. There is no treatment to prevent or delay the disease course of HDcurrently. Oxidative stress and mitochondrial dysfunction have emerged as key determinants of the disease progression in HD. Therefore, counteracting mutant huntingtin…(Read More)

DNP, mitochondrial uncoupling, and neuroprotection: A little dab’ll do ya

Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance tometabolic and oxidative stress. UCPs are induced by bioenergetic challenges such as caloric restriction and exercise and may protect neurons against dysfunction and degeneration. The pharmacological uncoupler 2,4-dinitrophenol (DNP), which was once prescribed to >100,000 people as…(Read More)

Fifteen Small Businesses that are Making a Splash in the Big City

Mitochon’s mission is to bring forward meaningful drugs that work at the root of insidious neurological diseases. By harnessing the power of the mitochondria, they believe that devastating diseases like Huntingtons disease, Duchennes muscular dystrophy and multiple sclerosis can be hastened and lives can be more fully lived…(Read More)

Mitochon Pharmaceuticals Raises $1.6M for Clinical Stage Development

The First Mitochondrial Targeted Agent to Treat Neurodegenerative Diseases Blue Bell, Pennsylvania (BUSINESS WIRE) — Mitochon Pharmaceuticals today announced completion of its second year of funding with a total investment of $1.6 million. The proceeds from the financing will be used to advance Mitochon’s lead compound MP101, a first in class mitochondrial targeted neuro…(Read More)

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