Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the first exon of the gene huntingtin. There is no treatment to prevent or delay the disease course of HDcurrently. Oxidative stress and mitochondrial dysfunction have emerged as key determinants of the disease progression in HD. Therefore, counteracting mutant huntingtin…(Read More)

Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance tometabolic and oxidative stress. UCPs are induced by bioenergetic challenges such as caloric restriction and exercise and may protect neurons against dysfunction and degeneration. The pharmacological uncoupler 2,4-dinitrophenol (DNP), which was once prescribed to >100,000 people as…(Read More)

Mitochon’s mission is to bring forward meaningful drugs that work at the root of insidious neurological diseases. By harnessing the power of the mitochondria, they believe that devastating diseases like Huntingtons disease, Duchennes muscular dystrophy and multiple sclerosis can be hastened and lives can be more fully lived…(Read More)

The First Mitochondrial Targeted Agent to Treat Neurodegenerative Diseases Blue Bell, Pennsylvania (BUSINESS WIRE) — Mitochon Pharmaceuticals today announced completion of its second year of funding with a total investment of $1.6 million. The proceeds from the financing will be used to advance Mitochon’s lead compound MP101, a first in class mitochondrial targeted neuro…(Read More)

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